What happens if I need to stop one or both medications
FIGURE 4 This is complicated because as a polar, charged tripeptide, transport of GSH is significantly inhibited by the blood-brain barrier (BBB), thus limiting effective delivery to brain-resident immune cells such as microglia which are central drivers of neuroinflammatory pathology (Valdovinos-Flores and Gonsebatt, 2012
Inter-individual variability in the absorption rate ( k a ), clearance (CL), intercompartmental clearance ( Q ), central volume ( V c ), and peripheral volume ( V p ) was explored using a log normal distribution in a model that included covariates with clear effects: drug product strength on the absorption rate constant and body weight as a covariate factor on CL, V c and V p
By combining these agents in a single injection, the formulation may improve patient adherence to treatment protocols while potentially reducing the burden side effects or and multiple injections or medications, as determined by necessary by the prescribing physician