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At least 10,000 cells per sample were analyzed in duplicates and classified into PMN and PBMC based on size and granularity by flow cytometry (FACSCantoII, BD Biosciences, San Jose, USA, Supplementary Figures 1A, D )
Both medications are FDA approved for Type 2 diabetes and, given their profound impact on weight loss, often prescribed off-label for obesity
the lack of a control group in that trial may lead to inaccurate conclusions
The cumulative effect of these factors - protection from digestive degradation, improved cellular uptake, sustained release, and reduced first-pass metabolism - is significantly enhanced bioavailability
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