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With regard to adverse effects, gastrointestinal intoleranceespecially nausea and vomitingrepresents the class-defining limitation
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Similarly, a high glucose level (25 mM) with 10 mM L-glutamine and 5 mM sodium butyrate, major physiological nutrients, promoted GLP-1 secretion and cAMP accumulation, both completely inhibited by 1-M pasireotide treatment in GLUTag cells (Fig
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