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Moreover, endothelial cell inflammation results in the proliferation, migration, and apoptosis of vascular smooth muscle cells (VSMCs), thereby fostering intimal thickening and vascular remodeling and accelerating the deposition of atherosclerotic plaques [6]

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Excessive intake has also been reported to lead to acid reflux, although scientific evidence does not support this ( If youre experiencing digestive problems as a result of taking too much vitamin C, you can simply cut back your supplement dose or avoid vitamin C supplements altogether ( Summary Ingesting more than 2,000 mg of vitamin C per day may lead to gastrointestinal upset, including symptoms like diarrhea and nausea