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Moreover, additional roles for GLP-1 have been revealed since the discovery of an extrapancreatic distribution of GLP-1 receptors in multiple organs such as the gastrointestinal tract, lung, heart, liver, and kidneys [58910], and evidence shows that administration of GLP-1 or GLP-1 RAs result in beneficial effects in these organs, indeed [11]

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After overnight incubation, flow cytometry revealed pSTAT5 activation in CD4, CD8, and CD56 cells only upon MMP7 treatment (Fig