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Fish Res 225:105479

Limitations of Simple Topical Application : The stratum corneum on the skin's surface is a powerful barrier, making it difficult for water-soluble ingredients like glutathione to penetrate deeply

Higher doses reaching up to 3x250mcg/daily have been reported anecdotally [45, 46]

Vitamin C is the best-studied and understood antioxidant: a substance that readily donates electrons to neutralize potentially damaging oxidative free radicals. As our cells use oxygen to make energy, they create oxygen free radicals, which must be tightly controlled or they can destroy DNA, proteins, and other key cell components