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Efficacy and safety of amylin-receptor agonists in metabolic-signaling research. Lancet-associated metabolic literature
doi:10.1186/s13054-024-05006-x 27
Yoon I, Kim S, Cho M, You KA, Son J, Lee C, et al
Example of toxic acetylated metabolite Liver damage Highly reactive specie Mechanism of acetylation Acetyl CoA is the activated carrier for acetyl group The reaction catalyzed by the soluble acetyltransferase enzyme: Mainly found in liver Might found in lung, spleen, GIT and red blood cells Acetylation The rate of acetylation is mainly affected by the existence of genetic polymorphism
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