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Glucocorticoids (oral prednisone, hydrocortisone) suppress the GH axis dose-dependently
Given that improvement in social deficits is observed following relatively short-term MT-II treatment, this is likely mediated by neuromodulatory signaling downstream of MC4R including increased oxytocin activity that overrides existing asocial structural abnormalities
However, its use beyond this approved indication, such as for erectile dysfunction in men, is considered off-label
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