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The metabolic state created by significant caloric restriction activates pathways that break down muscle tissue to provide amino acids for gluconeogenesis and other essential processes

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[91] Since only bacteria and some archea possess the genes and enzymes necessary to synthesize vitamin B 12 , plant and algae sources all obtain the vitamin secondarily from symbiosis with various species of bacteria, [5] or in the case of fermented plant foods, from bacterial fermentation

This makes it appealing for individuals who want to reduce body fat while maintaining lean muscle mass