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Fine lines and crow's feet soften over four to six weeks of consistent use, which is a slower change than the brightening and a more durable one

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6 When to speak to a healthcare professional Speak to your GP or a regulated UK clinician if you experience any of the following: Nausea or vomiting that lasts more than 24 hours, or that stops you from keeping fluids down Persistent or severe abdominal pain, especially if it radiates to your back (a possible sign of pancreatitis) Sudden, severe pain in the upper right side of your abdomen (a possible sign of gallstones or gallbladder inflammation) Persistent burning, tingling, or unusual skin sensitivity Palpitations, a sustained racing heart, dizziness, or chest discomfort Yellowing of the skin or eyes, dark urine, or pale stools (possible signs of liver problems) Signs of dehydration: dry mouth, low urine output, dizziness on standing, confusion Low mood, anxiety, or thoughts of self-harm If you bought retatrutide online and notice any new or unexpected symptoms Retatrutide isnt currently MHRA-approved