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GLP-1 receptor agonists (semaglutide, liraglutide, tirzepatide) do not list infertility as a recognised adverse effect in MHRA-approved product information
Biochemistry 46 , 90419049 (2007)
Key contraindications include: Personal or family history of medullary thyroid cancer (MTC) or multiple endocrine neoplasia type 2 (MEN2) : Animal studies show a link to thyroid tumors, so these drugs are avoided to prevent potential risks
HCC-specific data included alpha fetoprotein, maximum viable tumor diameter + number of viable tumors on imaging, receipt of locoregional therapy (LRT), and explant pathology data used to calculate RETREAT score
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