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Increasingly, theyre being used by more people to lose weight
20, 2026 JAMA, Discontinuation and Reinitiation of Dual-Labeled GLP-1 Receptor Agonists Among US Adults With Overweight or Obesity, Jan
[1] [2] Marketed under brand names including Ozempic, Wegovy, and Rybelsus, semaglutide works by mimicking the action of the naturally occurring hormone GLP-1, which enhances glucose-dependent insulin secretion, suppresses glucagon release, slows gastric emptying, and promotes satiety
This reduction in heat-generating capacity and insulation leads to increased cold sensitivity, particularly in the extremities
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