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Furthermore, emerging studies provide evidence that SGLT2-i might have an interfering effect on aldosterone/renin ratio (ARR) in patients with T2DM, due to their diuretic and sympathoinhibition effects
This sets off an immunological reaction, exacerbates inflammation, and throws your hormone system into disarray, particularly affecting the balance of estrogen and cortisol
These variable effective doses highlight the need for systematic dose-response studies to establish optimal dosing regimens
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