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Your healthcare provider can conduct appropriate investigations, which may include thyroid function tests, hormone levels, cardiovascular assessment, or review of glycaemic control through HbA1c and glucose monitoring

There is also a practical distinction between degradation that happens gradually at moderate temperatures and degradation that happens rapidly at extreme temperatures

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It is important to note that both human and hamster P-gp contain the same epitope sequence for C219 mAb [26], hence differences in antibody antigen binding is not responsible for differences in P-gp signal in the two cell lines