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Neuroscience 210:296307 Kocsis K, Knapp L, Meszaros J, Kis Z, Farkas T, Vecsei L, Toldi J (2015) Acetyl-l-carnitine and oxaloacetate in post-treatment against LTP impairment in a rat ischemia model
Thrombin mediates severe neurovascular injury during ischemia
However, these two natural GLP-1R agonists are rapidly digested by the enzyme DPP-4 and cleared by the kidneys within 1-2 minutes, making them unsuitable for direct therapeutic use
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