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Other ions, such as Na + , K + , Cl , and Zn 2+ , are required for lysosomal responses, including transportation, the maintenance of membrane potential, and the activation of lysosomal enzymes 33

30 U/mL) fully inhibited the formation of DEPMPO/ OOH (Fig

Thus, while each platform has demonstrated proof-of-concept efficacy, the choice of design must balance responsiveness, stability, and biosafety to ensure clinical applicability