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Moreover, mitochondrial apoptotic pathways may be triggered, where excessive ROS accumulation activates caspases and endonucleases, further degrading DNAan effect more pronounced in bucks due to their higher metabolic activity and mitochondrial ROS production (150, 151)
There is also a pipeline of novel drug candidates, such as small-molecule, once-a-month injectable, and dual-triple GLP-1 agonists with the GIP and glucagon receptors
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Metformin also has modest effects on weight, typically resulting in small reductions or weight stabilisation rather than significant loss
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