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Use a clean cloth or cotton pad and avoid aggressive rubbing, which can worsen irritation
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Start at 250 mcg Before Increasing If you plan to use 500 mcg daily, start at 250 mcg for the first 5-7 days
These mechanisms involve different steps which are currently not well-characterized: (1) entrance of Ca 2+ into the enterocytes through the Ca 2+ -selective transient receptor potential (TRP) channel TRPV6 and the voltage-gated calcium channel Cav1.3, a member of the L-type calcium channel family
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