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These selectivity studies, published by the Novo Nordisk programme and subsequent independent groups, established Ipamorelin as the first and defining selective GHS-R1a agonist and produced the reference dataset against which all subsequent selective GH secretagogue compounds are benchmarked
10.1371/journal.pone.0107272 183 XiongZ.LairdP
The constructed pURA3-GSH1 strain was heterozygous at the GSH1 locus, with one allele expressing the URA3 ORF under pGSH1 control and the other expressing GSH1 under pTEF1 control (FigureS1 A )
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