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The complex, multi-component nature of targeted and stimuli-responsive nanoplatforms complicates large-scale production, rigorous quality control, and the evaluation of long-term biocompatibility for novel biomaterials and metal-based nanoparticles (59, 68)
The Doses Phase 3 Trials Studied The full clinical development program for tirzepatide, called SURPASS for diabetes and SURMOUNT for obesity, evaluated three maintenance doses: 5 mg, 10 mg, and 15 mg once weekly
Weight loss may accelerate temporarily after a dose increase
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