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6 Semaglutide produced significantly greater weight loss (an 1112 kg difference versus placebo) and larger improvements in pain (Western Ontario and McMaster Universities Arthritis Index [WOMAC] score: 41.7 versus 27.5)

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The cellular consequence is increased eumelanin synthesis, documented in the B16-F10 (murine melanoma), MNT-1 (human melanoma), and primary human melanocyte cultures