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In the SURMOUNT-1 trial, participants receiving higher doses of tirzepatide achieved average weight loss approaching 20% of their starting body weight
The expression of the VD metabolism genes CYP2R1 and CYP27A1 (25-hydroxylase), CYP27B1 (1--hydroxylase), and vitamin D receptor (VDR) were downregulated in the livers of mice fed an HFD (GSH- deficient) compared with control diet-fed group
28.3% weight loss at 80 weeks
Oral GLP-1 RAs: Oral GLP-1 receptor agonists, like Rybelsus, are gaining traction due to their ease of administration and long-term management benefits
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