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Smoking Alcohol abuse Having endocrine-related autoimmune disorders (such as diabetes, or thyroid disorder) Gastrointestinal disorders such as Crohns disease Having undergone gastric bypass surgery or other surgeries that remove parts of the stomach

We separated nuclear and cytoplasmic proteins and calculated the ratio of p-P53 to total P53 in each fraction

This results in systemic signaling effects that extend beyond adipose tissue, making these compounds more suitable for studying integrated endocrine regulation rather than isolated metabolic pathways

To address these questions, we employed a genetic approach to investigate colocalization of LepRb and BDNF expression in the brain