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Zuckerman says that the rise of telemedicine and direct-to-consumer marketing, and a greater focus on lifestyle medications, has led to an increased interest in unapproved drugs such as peptide injectables

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Preclinical studies in rodents have shown an association between GLP-1 receptor activation and thyroid C-cell changes, although a direct causal link in humans has not been established, and UK/EU SmPCs for authorised GLP-1 RAs do not list MTC or MEN2 as a formal contraindication