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Degeneration of the lower motor neurons in the brainstem and spinal cord and the upper motor neurons in the motor cortex results in gradual denervation of voluntary muscles, leading to disruption of neural networks through a complex set of mechanisms eventually culminating in motor and non-motor symptoms (Table 2

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It was originally developed in the 1980s, at the University of Arizona, after it was found that a-MSH caused sexual arousal in rodents as well as darkening of the skin