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1985 Lecacheux, D., R
Retatrutide's approximately 6-day half-life directly supports a once-weekly subcutaneous injection regimen, maintaining relatively stable plasma drug levels between doses and mirroring the dosing schedules of other long-acting incretin-based therapies such as semaglutide and tirzepatide
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This includes maintaining a consistent sleep schedule, creating a restful sleeping environment (cool, dark, and quiet), avoiding stimulants like caffeine and nicotine close to bedtime, and limiting exposure to screens before sleep
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