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Second, "cleared from plasma" is not "gone." Metabolites, downstream biomarkers, and receptor-level effects can persist long after the parent compound has fallen below the limit of quantification, which is the single most misunderstood point in this whole topic

Preclinical studies suggest that ALCAR may increase neuroplasticity (the ability of neurons to create new connections) and neurogenesis (the growth of new brain cells) in the hippocampus (where emotional memories are stored) and prefrontal cortex (higher level thinking and modulation of emotional reactions) (Wang and Pae 2017)

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24 Instead, it appears to be highly modifiable