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Evaluation: Body fat (DXA scanning) Lean mass Insulin sensitivity Energy expenditure What they found: The combination showed an additive effect on fat reduction vs monotherapy AOD-9604 partially protected lean mass during GLP-1-induced weight reduction Increased energy expenditure in combination (~3 % vs GLP-1 alone) No new safety signals Why it matters: It validates the concept of combination , the idea that AOD-9604 may not work on its own, but can add value in combination with incretin agonists
J Neurol Sci 1994, 12(2):140143
It stimulates fat breakdown and oxidation while helping prevent new fat storage, particularly in areas where stubborn fat tends to accumulate
Very high doses (such as those used for cyanide poisoning) should be used with caution and only if the potential benefit outweighs the risk
