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The current role of sodium-glucose cotransporter 2 inhibitors in type 2 diabetes mellitus management
(106) included seven randomized, placebo-controlled trials that exclusively enrolled individuals with high blood pressure, i.e., with systolic blood pressure (SBP) 140 mm Hg and/or diastolic blood pressure (DBP) 90 mm Hg
Therefore, there appear to be as yet unknown pathways by which metformin can acutely increase GLP-1 secretion
This insight, which implied that a substance could be harmful at a high dose but beneficial or benign at a low one, directly prefigured the biphasic dose-responses central to hormesis and laid the groundwork for modern toxicology
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