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Ferroptosis, a form of regulated cell death initiated by lipid peroxidation, differs from other types of cell deaths at genetic, biochemical, and morphological levels 24,25

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Epigenetically, -KG modulates histone H3K27me3 levels, influencing the expression of genes like Col3A1 (but not PLK1), thereby contributing to fibroblast phenotype regulation [103]

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