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Binding affinity data from Hruby and colleagues' foundational work at Arizona (published through the 1990s and 2000s in the Journal of Medicinal Chemistry) established that MT2 has substantially greater potency than alpha-MSH across the receptor panel, with a particularly pronounced gain at MC4R relative to MC1R
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& Dolg, M
Binding to the EPORCD131 receptor complex, ARA-290 activates signaling cascades (e.g., JAK/STAT, PI3K/Akt) associated with cell survival, reduced apoptosis, and decreased pro-inflammatory cytokine production
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