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This results in excessive release of dopamine, norepinephrine, and serotonin, which overstimulate postsynaptic receptors and produce the euphoric and stimulant effects associated with METH use (Lee et al., 2009

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Furthermore, the loss of GPX4 impairs the ability of pharmacological interventions like TA to effectively mitigate ER stress, underlining the importance of GPX4 in maintaining cellular homeostasis under conditions of stress

DLS measurements revealed a slightly larger size than that of blank liposomes, indicating successful drug incorporation (Figure S11C)