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Clinical Evidence Supporting Semaglutide in PCOS Management Randomized controlled trials have demonstrated that GLP-1 receptor agonists improve insulin sensitivity (measured by HOMA-IR scores) in PCOS populations by 2035%, independent of weight loss alone

Daniel Drucker, a clinician-scientist at the Lunenfeld-Tanenbaum Research Institute at Toronto's Mount Sinai Hospital who helped lay the foundation for these drugs, called the study a powerful analysis

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As weight decreases, the body may use energy differently