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Together, they both increase production and enhance release, creating a powerful anabolic and anti-catabolic environment even during caloric restriction

Future trials with larger sample sizes will be needed to determine whether semaglutide alone or in combination with other liver-targeted agents will improves outcomes such as liver-related morbidity and mortality in patients with NASH and compensated cirrhosis, Loomba said

The primary endpoint was a composite of death from cardiovascular causes, non-fatal MI or non-fatal stroke, with a significant 20% reduction in the semaglutide group versus placebo

A 2022 commentary in Wound Repair and Regeneration stated: "Fewer than 15% of compounds showing efficacy in rodent wound models achieve statistical significance in Phase III human wound trials" [8]