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Seeley, University of Michigan) and Wnt1-Cre2 mice were bred at Mount Sinai Hospital (Toronto, Canada), as previously described 19,20 , to produce a CNS knockdown of the Glp1r ( Glp1r Wnt1/ )
Wegovy tablets may appeal to people who want to avoid injections, but Mounjaro currently has stronger clinical trial results and is already available in the UK
It would therefore be interesting to determine if the opposite approach, i.e., simultaneously inhibiting ARC AgRP/NPY neurons and activating ARC POMC neurons, additively reduces food intake and leads to weight loss in the chronic setting as this would be therapeutically relevant
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