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Albuterol selectively binds receptors on bronchial smooth muscle, activating Gs-proteincoupled adenylyl cyclase and increasing intracellular cyclic AMP (cAMP)

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These pathways produce NAD + which can be used to convert glutamate to -ketoglutarate via NAD + -dependent GDH2

Christakis I, Silva AM, Williams MD, Garden A, Grubbs EG, Busaidy NL, Lee JE, Perrier ND, Zafereo ME