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Notably, the deletion of lipogenic enzymes in the liver, such as acetyl-CoA carboxylase 1/2 (ACC1/2), has been reported to liberate NADPH for antioxidant processes, including GSH regeneration 87

Severe Kidney Disease: Carnitine is processed by the kidneys, and in individuals with severe kidney disease, it can accumulate in the body, potentially leading to toxicity