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Ongoing Monitoring At Each Follow-Up Visit: Ask specifically about tingling, numbness, burning sensations Check sensation in hands and feet Document any new symptoms Assess impact on quality of life Consider Dose Reduction If: Mild dysesthesia present but tolerable Patient achieving good weight loss (can afford slightly less efficacy) Symptoms are bothersome but not severe Consider Discontinuation If: Moderate to severe dysesthesia Progressive symptoms despite dose reduction Functional impairment Patient preference to stop Long-Term Unknowns and Research Needs Critical Questions for Future Studies 1
Changes in appetite, digestion, and energy often show up before consistent changes in weight, and progress doesnt always happen at a steady pace
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10.1016/j.intimp.2021.107600 319 WangY.XuC.-F.LiuY.-J.MaoY.-F.LvZ.LiS.-Y.et al (2017)
