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Due to their high reactivity, HO can react with various biomolecules and are important participants in oxidative stress processes [51]
Some users optimize at 1%, others at 3% or higher
Low glutathione levels have been linked to an increased risk of arthritis, cancer, cardiovascular disease, diabetes, gut issues, and more, so this isnt something you should ignore
The one human trial that will measure tolerability directly has not started reporting it is only recruiting (planned 2026), studies a topical gel on small standardized wounds , and lists safety as a secondary, not primary, outcome (NCT07437586)
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