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Topical Use Safety Profile Studies report minimal side effects, though mild irritation may occur in sensitive individuals
However, nausea is the most commonly reported adverse effect, with incidence varying by medication and dose: approximately 15-30% for most GLP-1 agonists and up to 30-44% at higher doses of semaglutide and tirzepatide according to FDA prescribing information
doi: 10.3803/EnM.2021.1293 98 LeeY-SParkM-SChoungJ-SKimS-SOhH-HChoiC-Set al
It supports fading of dark spots and hyperpigmentation while improving overall skin brightness
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