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adding his own thoughts: Study in 407 patients with mean age was 56, mean BMI 40.3, and mean WOMAC pain score 70.9 who had obesity & knee osteoarthritis with moderate-to-severe pain, treatment with once-weekly injectable semaglutide resulted in significantly greater reductions in body weight and pain related to knee osteoarthritis. Once-Weekly Semaglutide in Persons with Obesity and Knee Osteoarthritis Authors: Henning Bliddal, M.D., Harold Bays, M.D., Sbastien Czernichow, M.D., Ph.D., Joanna Uddn Hemmingsson, M.D., Ph.D., Jran Hjelmesth, M.D., Ph.D., Thomas Hoffmann Morville, M.D., Ph.D., Anna Koroleva, M.D., Jesper Skov Neergaard, Ph.D., Patricia Vlez Snchez, M.D., Sean Wharton, M.D., Alicja Wizert, Ph.D., and Lars E

Visible weight loss begins appearing around weeks 6-8 as cumulative loss reaches 8-12 pounds

In contrast, unilateral reactivation markedly improved hyperinsulinemia and normalized blood glucose levels and locomotor activity (Coppari et al., 2005)

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