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research grant from Astellas, Bayer, Boehringer Ingelheim Japan, Fuji, Mochida, and Novartis
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The L-Cell in Nutritional Sensing and the Regulation of Appetite
Its main actions include: Stimulating insulin secretion from pancreatic beta cells in a glucose-dependent manner Suppressing glucagon release, which reduces hepatic glucose production Slowing gastric emptying, which moderates post-meal glucose spikes Promoting satiety through central nervous system pathways, thereby reducing appetite GIP is released by K-cells in the proximal small intestine and shares some functions with GLP-1, particularly in enhancing insulin secretion after meals
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