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GLP-1R agonists represents a novel class of anti-hyperglycemic agent that improve health and survival of -cells (improvement in postprandial hyperglycemia), suppress glucagon (improvement in fasting hyperglycemia), improve insulin resistance (modest effect) and influence energy intake (augment satiety signal) with minimal, if at all, any side effects (weight neutral and non-hypoglycemic)
To elucidate the effect of GCLC and glutathione loss on brain homeostasis, we biochemically and histochemically analyzed brain pathologies in neuronal GCLC-conditional knockout (GCLC floxed X CaMKII-Cre
More broadly, our findings suggest that GLP1R agonists could have applications in disorders of dysregulated reward signalling, including substance-use disorders
Nerve damage can be challenging to heal, as nerves have limited regenerative capacity
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