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458 Specifically, in response to Frataxin deficiency, the activation of iron-responsive element binding protein 1 (Fe-S protein) increases cellular iron uptake, with the iron being translocated into mitochondria via mitochondrial iron transporters in an attempt to compensate for impaired Fe-S cluster biogenesis
This results in the recruitment of immune cells and the release of pro-inflammatory cytokines, which in turn influence keratinocyte and fibroblast activity [43, 47]
The following are absorbable forms of glutathione available: S-acetyl glutathione is probably the most accessible form of glutathione and comes in capsules that the intestinal tract can efficiently absorb
