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At the maximum dose of 2.4 mg weekly, participants achieved approximately 17-22% weight reduction from baseline
46.31 7.56 kg/m 2
Guastellas work has been foundational in both establishing the behavioral effects of intranasal oxytocin in human subjects and in critically examining where earlier optimism may have outpaced methodological rigor
31 In a trial evaluating semaglutide for weight loss, the incidence of acute pancreatitis was still low (3 of 1,306 participants) despite a higher dose and more significant weight loss, but none of the 655 individuals in the placebo group developed pancreatitis
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