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In APP/PS1 mice, the cognitive improvement observed after ip administration of liraglutide was accompanied by decreased activation of microglia [66]

A candidate for a potential glutathione-scaffold residue was identified using the following selection criteria: The residue should be rather conserved in enzymatically active in contrast to inactive glutaredoxins and have a charged side chain to ensure a strong ionic glutathione interaction (Fig

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There will certainly be many arguments among experts as to whether this study met a minimum threshold for neuroprotection (preventing brain cells from dying), and my personal opinion would be a cautious MAYBE . The assessment of neuroprotection does not in general have a specific accepted and associated metric (way to measure it), so neuroprotection is largely based on the interpretation of scientists and clinicians