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In our cohort, semaglutide use was associated with a modest reduction in HbA1c (0.31 2.57%, p = 0.630) and a numerically large but statistically non-significant reduction in body weight (12.63 24.03 kg, p = 0.074)
While systemic injection also delivers peptides to the brain via blood circulation, nasal delivery may provide more direct CNS access for some portion of the dose
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This helps optimize absorption and avoids over-saturation Switch Nostrils : Use the other nostril for the next dose
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