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HFD impairs liver glutathione biosynthesis, vitamin D metabolism genes and genes associated with non-alcoholic fatty liver disease (NAFLD) Genes involved in the GSH biosynthesis pathway were significantly downregulated in the livers of mice fed an HFD compared to those of mice fed a healthy diet (controls) (Fig
a phase 2 trial published in the New England Journal of Medicine (Jastreboff et al., 2023) demonstrated significant weight reduction in adults with obesity, and further trials are ongoing (see ClinicalTrials.gov for current study identifiers)
Xiaosong M, Jens B, Frances MA
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