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Itchy E3 ubiquitin protein ligase (ITCH), also known as AIP4, a HECT-type E3 ubiquitin ligasefunctions in tight coordination with USP8 during extrinsic apoptotic signaling [70]
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The dorsal putamen was selected as the center of the volume of interest due to its relatively homogenous mix of neurons and astrocytes, and suitable distance from bone and other regions that could compromise signal quality
[1] [8] As a dual agonist, tirzepatide activates both GIP and GLP-1 receptors, which are incretin hormones that play crucial roles in glucose homeostasis and metabolic regulation
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