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Rare (may affect up to 1 in 1,000 people) serious allergic reactions (anaphylactic reactions)
Weight Loss Outcomes After Switching Trial data supports a higher average weight loss ceiling on tirzepatide: 20.9% at 72 weeks on 15mg (SURMOUNT-1) versus 14.9% at 68 weeks on 2.4mg semaglutide (STEP 1)
The first converts homocysteine to methionine, which supports DNA synthesis and red cell production
There may be direct pharmacological effects through central GLP-1 pathways, as well as indirect consequences of the medication's intended actions and associated side effects
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